I think I was one of the few people who used WinME and loved it! I never had an issue with it. I remember it had more features than 98 and looked better as well.
Unreal was the first game I played on WinME and is still one of my all time favourite games! The only reason I initially went to WinXP was because WinME couldn't use more than 512MB of RAM.
I'm currently using WinXP-Pro and looking at going to Win7 next year sometime. I'll always have a WinXP drive on my comp as some games I play don't like Vista and Win7
Vietcong doesn't like Vista+ due to it not liking DirectX 10 which causes random crashing and the anti-cheat system
HradBa thinks DirectX10 is a hack and gives a false-positive Code 149 (Direct3D altering) kick.
Far Cry 2 apparently won't currently work drama-free on Win7
"Windows 7 isn't supported" -
link -