Loving it. I cheer everytime I run into an old friend from the last game.
The only annoying thing is that is once again has that map scenario where you scan planets to find things. In ME2 that was the main flaw in the game imo. It was just irritating to do.
Welll they still have that in a way. Slightly less annoying but still just silly. But the rest of the game is practically flawless, the world is beautiful, the characters are great. Love it.
Edit: a lot of people have been complaining about the graphics, but they look great to me. The odd texture is obviously crap but the main part are fantastic and you are talking about hours of cut scenes and dialogue.
One thing which people have been justifably annoyed about is the low FOV. I had a headache after playing the game for 2 hours last night because the FOV is so small/squashed.
This fixes it: http://widescreengamingforum.com/comment/242894